November 25, 2017 - 4 million BTC lost (Estimation)

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Chainalysis, a cryptocurrency and blockchain analytics company, first revealed in an interview with Fortune that between 2.78 and 3.79 million BTC are already lost on the bitcoin blockchain. That number was released in November 2017.

Chainalysis’s conclusions rely on segmenting the existing bitcoin supply based on age and transaction activity. For some segments, the company used statistical sampling to determine the amount lost.

Source: Fortune